Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis

Platelet-decorated von Willebrand factor (VWF) strings anchored to the endothelial surface are rapidly cleaved by ADAMTS13. Individual VWF string characteristics such as number, location, and auxiliary features of the ADAMTS13 cleavage sites were explored here using imaging and computing software. B...

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Detalhes bibliográficos
Main Authors: De Ceunynck, Karen, Rocha, Susana, Feys, Hendrik B., De Meyer, Simon F., Uji-i, Hiroshi, Deckmyn, Hans, Hofkens, Johan, Vanhoorelbeke, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196129/
https://ncbi.nlm.nih.gov/pubmed/21896483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271890
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