Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis

Platelet-decorated von Willebrand factor (VWF) strings anchored to the endothelial surface are rapidly cleaved by ADAMTS13. Individual VWF string characteristics such as number, location, and auxiliary features of the ADAMTS13 cleavage sites were explored here using imaging and computing software. B...

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Autores principales: De Ceunynck, Karen, Rocha, Susana, Feys, Hendrik B., De Meyer, Simon F., Uji-i, Hiroshi, Deckmyn, Hans, Hofkens, Johan, Vanhoorelbeke, Karen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196129/
https://ncbi.nlm.nih.gov/pubmed/21896483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271890
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