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Male infertility-linked point mutation disrupts the Ca(2+) oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ
A male infertility-linked human PLCζ (phospholipase Cζ) mutation introduced into mouse PLCζ completely abolishes both in vitro PIP(2) (phosphatidylinositol 4,5-bisphosphate) hydrolysis activity and the ability to trigger in vivo Ca(2+) oscillations in mouse eggs. Wild-type PLCζ initiated a normal pa...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195387/ https://ncbi.nlm.nih.gov/pubmed/21204786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101772 |
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