Is PAWP the “real” sperm factor?

Por Nomikos, Michail, Swann, Karl, Lai, F Anthony
Publicado no Asian J Androl (2015)

Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ

Por Sanusi, Randa, Yu, Yuansong, Nomikos, Michail, Lai, F. Anthony, Swann, Karl
Publicado no Mol Hum Reprod (2015)

PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2)

Por Yu, Yuansong, Nomikos, Michail, Theodoridou, Maria, Nounesis, George, Lai, F. Anthony, Swann, Karl
Publicado em 2012

Phospholipase Cζ binding to PtdIns(4,5)P(2) requires the XY-linker region

Por Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian L., Nounesis, George, Swann, Karl, Lai, F. Anthony
Publicado em 2011

The dynamics of MAPK inactivation at fertilization in mouse eggs

Por Gonzalez-Garcia, Jose Raul, Bradley, Josephine, Nomikos, Michail, Paul, Laboni, Machaty, Zoltan, Lai, F. Anthony, Swann, Karl
Publicado em 2014

Male infertility-linked point mutation disrupts the Ca(2+) oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ

Por Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian L., Cumbes, Bevan, Nounesis, Georg, Swann, Karl, Lai, F. Anthony
Publicado em 2011

Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca(2+) release in mouse oocytes

Por Nomikos, Michail, Sanders, Jessica R., Theodoridou, Maria, Kashir, Junaid, Matthews, Emily, Nounesis, George, Lai, F. Anthony, Swann, Karl
Publicado em 2014

Ca(2+) dynamics in oocytes from naturally-aged mice

Por Haverfield, Jenna, Nakagawa, Shoma, Love, Daniel, Tsichlaki, Elina, Nomikos, Michail, Lai, F. Anthony, Swann, Karl, FitzHarris, Greg
Publicado no Sci Rep (2016)

Novel regulation of PLCζ activity via its XY-linker

Por Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Georgilis, Athena, Gonzalez-Garcia, J. Raul, Nounesis, George, Swann, Karl, Lai, F. Anthony
Publicado em 2011

Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation

Por Nomikos, Michail, Theodoridou, Maria, Elgmati, Khalil, Parthimos, Dimitris, Calver, Brian L., Buntwal, Luke, Nounesis, George, Swann, Karl, Lai, F. Anthony
Publicado em 2014

Phospholipase C-ζ-induced Ca(2+) oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection

Por Swann, Karl, Windsor, Shane, Campbell, Karen, Elgmati, Khalil, Nomikos, Michail, Zernicka-Goetz, Magdalena, Amso, Nazar, Lai, F. Anthony, Thomas, Adrian, Graham, Christopher
Publicado em 2012

Divergent effect of mammalian PLCζ in generating Ca(2+) oscillations in somatic cells compared with eggs

Por Phillips, Sally V., Yu, Yuansong, Rossbach, Andreas, Nomikos, Michail, Vassilakopoulou, Vyronia, Livaniou, Evangelia, Cumbes, Bevan, Lai, F. Anthony, George, Christopher H., Swann, Karl
Publicado em 2011

Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca(2+) oscillations in mammalian eggs at fertilization

Por Theodoridou, Maria, Nomikos, Michail, Parthimos, Dimitris, Gonzalez-Garcia, J. Raul, Elgmati, Khalil, Calver, Brian L., Sideratou, Zili, Nounesis, George, Swann, Karl, Lai, F. Anthony
Publicado em 2013

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility

Por Nomikos, Michail, Yu, Yuansong, Elgmati, Khalil, Theodoridou, Maria, Campbell, Karen, Vassilakopoulou, Vyronia, Zikos, Christos, Livaniou, Evangelia, Amso, Nazar, Nounesis, George, Swann, Karl, Lai, F. Anthony
Publicado em 2013

Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP(2))

Por Nomikos, Michail, Sanders, Jessica R., Parthimos, Dimitris, Buntwal, Luke, Calver, Brian L., Stamatiadis, Panagiotis, Smith, Adrian, Clue, Matthew, Sideratou, Zili, Swann, Karl, Lai, F. Anthony
Publicado no J Biol Chem (2015)