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Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca(2+) oscillations in mammalian eggs at fertilization
Phospholipase C-zeta (PLCζ) is a sperm-specific protein believed to cause Ca(2+) oscillations and egg activation during mammalian fertilization. PLCζ is very similar to the somatic PLCδ1 isoform but is far more potent in mobilizing Ca(2+) in eggs. To investigate how discrete protein domains contribu...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843027/ https://ncbi.nlm.nih.gov/pubmed/24152875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gat070 |
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