Novel regulation of PLCζ activity via its XY-linker

The XY-linker region of somatic cell PLC (phospholipase)-β, -γ, -δ and -ϵ isoforms confers potent catalytic inhibition, suggesting a common auto-regulatory role. Surprisingly, the sperm PLCζ XY-linker does not mediate auto-inhibition. Unlike for somatic PLCs, the absence of the PLCζ XY-linker signif...

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Detalhes bibliográficos
Main Authors: Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Georgilis, Athena, Gonzalez-Garcia, J. Raul, Nounesis, George, Swann, Karl, Lai, F. Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2011
Assuntos:
Accelerated Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195331/
https://ncbi.nlm.nih.gov/pubmed/21767260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110953
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