Clinically Relevant Plasma Concentrations of Colistin in Combination with Imipenem Enhance Pharmacodynamic Activity against Multidrug-Resistant Pseudomonas aeruginosa at Multiple Inocula

The use of combination antibiotic therapy may be beneficial against rapidly emerging resistance in Pseudomonas aeruginosa. The aim of this study was to systematically investigate in vitro bacterial killing and resistance emergence with colistin alone and in combination with imipenem against multidru...

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Detalhes bibliográficos
Main Authors: Bergen, Phillip J., Forrest, Alan, Bulitta, Jürgen B., Tsuji, Brian T., Sidjabat, Hanna E., Paterson, David L., Li, Jian, Nation, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195049/
https://ncbi.nlm.nih.gov/pubmed/21876058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05028-11
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