Clinically Relevant Plasma Concentrations of Colistin in Combination with Imipenem Enhance Pharmacodynamic Activity against Multidrug-Resistant Pseudomonas aeruginosa at Multiple Inocula

The use of combination antibiotic therapy may be beneficial against rapidly emerging resistance in Pseudomonas aeruginosa. The aim of this study was to systematically investigate in vitro bacterial killing and resistance emergence with colistin alone and in combination with imipenem against multidru...

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Bibliographische Detailangaben
Hauptverfasser: Bergen, Phillip J., Forrest, Alan, Bulitta, Jürgen B., Tsuji, Brian T., Sidjabat, Hanna E., Paterson, David L., Li, Jian, Nation, Roger L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195049/
https://ncbi.nlm.nih.gov/pubmed/21876058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05028-11
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