The Combination of Colistin and Doripenem Is Synergistic against Klebsiella pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance. A one-compartment in vitro pharmacokinetic/pharm...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Deris, Zakuan Z., Yu, Heidi H., Davis, Kathryn, Soon, Rachel L., Jacob, Jovan, Ku, Caron K., Poudyal, Anima, Bergen, Phillip J., Tsuji, Brian T., Bulitta, Jurgen B., Forrest, Alan, Paterson, David L., Velkov, Tony, Li, Jian, Nation, Roger L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457376/
https://ncbi.nlm.nih.gov/pubmed/22802247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01064-12
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items