The Combination of Colistin and Doripenem Is Synergistic against Klebsiella pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance. A one-compartment in vitro pharmacokinetic/pharm...

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Main Authors: Deris, Zakuan Z., Yu, Heidi H., Davis, Kathryn, Soon, Rachel L., Jacob, Jovan, Ku, Caron K., Poudyal, Anima, Bergen, Phillip J., Tsuji, Brian T., Bulitta, Jurgen B., Forrest, Alan, Paterson, David L., Velkov, Tony, Li, Jian, Nation, Roger L.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457376/
https://ncbi.nlm.nih.gov/pubmed/22802247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01064-12
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