The Combination of Colistin and Doripenem Is Synergistic against Klebsiella pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance. A one-compartment in vitro pharmacokinetic/pharm...

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Bibliographic Details
Main Authors: Deris, Zakuan Z., Yu, Heidi H., Davis, Kathryn, Soon, Rachel L., Jacob, Jovan, Ku, Caron K., Poudyal, Anima, Bergen, Phillip J., Tsuji, Brian T., Bulitta, Jurgen B., Forrest, Alan, Paterson, David L., Velkov, Tony, Li, Jian, Nation, Roger L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457376/
https://ncbi.nlm.nih.gov/pubmed/22802247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01064-12
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