The Combination of Colistin and Doripenem Is Synergistic against Klebsiella pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance. A one-compartment in vitro pharmacokinetic/pharm...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Deris, Zakuan Z., Yu, Heidi H., Davis, Kathryn, Soon, Rachel L., Jacob, Jovan, Ku, Caron K., Poudyal, Anima, Bergen, Phillip J., Tsuji, Brian T., Bulitta, Jurgen B., Forrest, Alan, Paterson, David L., Velkov, Tony, Li, Jian, Nation, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457376/
https://ncbi.nlm.nih.gov/pubmed/22802247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01064-12
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados