Synergistic Killing of Multidrug-Resistant Pseudomonas aeruginosa at Multiple Inocula by Colistin Combined with Doripenem in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Combination therapy may be required for multidrug-resistant (MDR) Pseudomonas aeruginosa. The aim of this study was to systematically investigate bacterial killing and emergence of colistin resistance with colistin and doripenem combinations against MDR P. aeruginosa. Studies were conducted in a one...

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Bibliographic Details
Main Authors: Bergen, Phillip J., Tsuji, Brian T., Bulitta, Jurgen B., Forrest, Alan, Jacob, Jovan, Sidjabat, Hanna E., Paterson, David L., Nation, Roger L., Li, Jian
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Susceptibility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232764/
https://ncbi.nlm.nih.gov/pubmed/21911563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05298-11
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