Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Somatic loss-of-function mutations in the ten-eleven-translocation-2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in the hematopoietic...

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Main Authors: Moran-Crusio, Kelly, Reavie, Linsey, Shih, Alan, Abdel-Wahab, Omar, Ndiaye-Lobry, Delphine, Lobry, Camille, Figueroa, Maria E., Vasanthakumar, Aparna, Patel, Jay, Zhao, Xinyang, Perna, Fabiana, Pandey, Suveg, Madzo, Jozef, Song, Chunxiao, Dai, Qing, He, Chuan, Ibrahim, Sherif, Beran, Miloslav, Zavadil, Jiri, Nimer, Stephen D., Melnick, Ari, Godley, Lucy A., Aifantis, Iannis, Levine, Ross L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194039/
https://ncbi.nlm.nih.gov/pubmed/21723200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.06.001
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