BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

Generation of induced pluripotent stem cells by defined factors has become a useful model to investigate the mechanism of reprogramming and cell fate determination. However, the precise mechanism of factor-based reprogramming remains unclear. Here, we show that Klf4 mainly acts at the initial phase...

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Autors principals: Chen, Jiekai, Liu, Jing, Yang, Jiaqi, Chen, You, Chen, Jing, Ni, Su, Song, Hong, Zeng, Lingwen, Ding, Ke, Pei, Duanqing
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193408/
https://ncbi.nlm.nih.gov/pubmed/21135873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.172
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