Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

Ectopic expression of defined transcription factors can reprogram somatic cells to induced pluripotent stem (iPS) cells, but the utility of iPS cells is hampered by the use of viral delivery systems. Small molecules offer an alternative to replace virally transduced transcription factors with chemic...

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Detalhes bibliográficos
Main Authors: Lyssiotis, Costas A., Foreman, Ruth K., Staerk, Judith, Garcia, Michael, Mathur, Divya, Markoulaki, Styliani, Hanna, Jacob, Lairson, Luke L., Charette, Bradley D., Bouchez, Laure C., Bollong, Michael, Kunick, Conrad, Brinker, Achim, Cho, Charles Y., Schultz, Peter G., Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690053/
https://ncbi.nlm.nih.gov/pubmed/19447925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903860106
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