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OCT4 and SOX2 work as transcriptional activators in reprogramming human fibroblasts
SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs) but it is unclear if they function as transcriptional activators or as repressors. We now show that, like OCT4, SOX2 functions as a transcriptional activator. We...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5648000/ https://ncbi.nlm.nih.gov/pubmed/28813671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.071 |
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