Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency

Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functi...

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Detalhes bibliográficos
Main Authors: Hammachi, Fella, Morrison, Gillian M., Sharov, Alexei A., Livigni, Alessandra, Narayan, Santosh, Papapetrou, Eirini P., O'Malley, James, Kaji, Keisuke, Ko, Minoru S.H., Ptashne, Mark, Brickman, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778438/
https://ncbi.nlm.nih.gov/pubmed/22832160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2011.12.002
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