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Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming
The success of Yamanaka factor reprogramming of somatic cells into induced pluripotent stem cells suggests that some factor(s) must remodel the nuclei from a condensed state to a relaxed state. How factor‐dependent chromatin opening occurs remains unclear. Using FRAP and ATAC‐seq, we found that Oct4...
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| 出版年: | EMBO J |
|---|---|
| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6939195/ https://ncbi.nlm.nih.gov/pubmed/31571238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899165 |
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