Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming

The success of Yamanaka factor reprogramming of somatic cells into induced pluripotent stem cells suggests that some factor(s) must remodel the nuclei from a condensed state to a relaxed state. How factor‐dependent chromatin opening occurs remains unclear. Using FRAP and ATAC‐seq, we found that Oct4...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Chen, Keshi, Long, Qi, Xing, Guangsuo, Wang, Tianyu, Wu, Yi, Li, Linpeng, Qi, Juntao, Zhou, Yanshuang, Ma, Bochao, Schöler, Hans R, Nie, Jinfu, Pei, Duanqing, Liu, Xingguo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939195/
https://ncbi.nlm.nih.gov/pubmed/31571238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899165
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