Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming

The success of Yamanaka factor reprogramming of somatic cells into induced pluripotent stem cells suggests that some factor(s) must remodel the nuclei from a condensed state to a relaxed state. How factor‐dependent chromatin opening occurs remains unclear. Using FRAP and ATAC‐seq, we found that Oct4...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Chen, Keshi, Long, Qi, Xing, Guangsuo, Wang, Tianyu, Wu, Yi, Li, Linpeng, Qi, Juntao, Zhou, Yanshuang, Ma, Bochao, Schöler, Hans R, Nie, Jinfu, Pei, Duanqing, Liu, Xingguo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939195/
https://ncbi.nlm.nih.gov/pubmed/31571238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899165
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