Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

Human-induced pluripotent stem cells (hiPSCs) are generated from somatic cells by ectopic expression of the 4 reprogramming factors (RFs) Oct-4, Sox2, Klf4, and c-Myc. To better define the stoichiometric requirements and dynamic expression patterns required for successful hiPSC induction, we generat...

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Autores principales: Papapetrou, Eirini P., Tomishima, Mark J., Chambers, Stuart M., Mica, Yvonne, Reed, Evan, Menon, Jayanthi, Tabar, Viviane, Mo, Qianxing, Studer, Lorenz, Sadelain, Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722286/
https://ncbi.nlm.nih.gov/pubmed/19549847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904825106
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