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BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone
Generation of induced pluripotent stem cells by defined factors has become a useful model to investigate the mechanism of reprogramming and cell fate determination. However, the precise mechanism of factor-based reprogramming remains unclear. Here, we show that Klf4 mainly acts at the initial phase...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193408/ https://ncbi.nlm.nih.gov/pubmed/21135873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.172 |
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