Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer’s disease (AD). The APOE ε4 allele dramatically increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Castellano, Joseph M., Kim, Jungsu, Stewart, Floy R., Jiang, Hong, DeMattos, Ronald B., Patterson, Bruce W., Fagan, Anne M., Morris, John C., Mawuenyega, Kwasi G., Cruchaga, Carlos, Goate, Alison M., Bales, Kelly R., Paul, Steven M., Bateman, Randall J., Holtzman, David M.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192364/
https://ncbi.nlm.nih.gov/pubmed/21715678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002156
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki