Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer’s disease (AD). The APOE ε4 allele dramatically increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the...

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Main Authors: Castellano, Joseph M., Kim, Jungsu, Stewart, Floy R., Jiang, Hong, DeMattos, Ronald B., Patterson, Bruce W., Fagan, Anne M., Morris, John C., Mawuenyega, Kwasi G., Cruchaga, Carlos, Goate, Alison M., Bales, Kelly R., Paul, Steven M., Bateman, Randall J., Holtzman, David M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192364/
https://ncbi.nlm.nih.gov/pubmed/21715678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002156
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