Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer’s disease (AD). The APOE ε4 allele dramatically increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the...

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Bibliografiset tiedot
Päätekijät: Castellano, Joseph M., Kim, Jungsu, Stewart, Floy R., Jiang, Hong, DeMattos, Ronald B., Patterson, Bruce W., Fagan, Anne M., Morris, John C., Mawuenyega, Kwasi G., Cruchaga, Carlos, Goate, Alison M., Bales, Kelly R., Paul, Steven M., Bateman, Randall J., Holtzman, David M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192364/
https://ncbi.nlm.nih.gov/pubmed/21715678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002156
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