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Metformin prevents tobacco carcinogen-induced lung tumorigenesis

Activation of the mTOR pathway is an important and early event in tobacco carcinogen-induced lung tumorigenesis, and therapies that target mTOR could be effective in the prevention or treatment of lung cancer. The biguanide metformin, which is widely prescribed for the treatment of type II diabetes,...

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Bibliografske podrobnosti
Main Authors: Memmott, Regan M., Mercado, Jose R., Maier, Colleen R., Kawabata, Shigeru, Fox, Stephen D., Dennis, Phillip A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192328/
https://ncbi.nlm.nih.gov/pubmed/20810672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0055
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