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Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau
Hyperphosphorylated tau has long been proposed as the key molecule disrupting normal neuronal microtubule dynamics and leading to neurofibrillary degeneration in Alzheimer disease. Here we provide a direct evidence of hyperphosphorylated tau-induced disruption of microtubule network. Using Nocodozol...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3191942/ https://ncbi.nlm.nih.gov/pubmed/17372746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-007-0207-8 |
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