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Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau

Hyperphosphorylated tau has long been proposed as the key molecule disrupting normal neuronal microtubule dynamics and leading to neurofibrillary degeneration in Alzheimer disease. Here we provide a direct evidence of hyperphosphorylated tau-induced disruption of microtubule network. Using Nocodozol...

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Autors principals: Li, Bin, Chohan, Muhammad Omar, Grundke-Iqbal, Inge, Iqbal, Khalid
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191942/
https://ncbi.nlm.nih.gov/pubmed/17372746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-007-0207-8
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