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Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau

Hyperphosphorylated tau has long been proposed as the key molecule disrupting normal neuronal microtubule dynamics and leading to neurofibrillary degeneration in Alzheimer disease. Here we provide a direct evidence of hyperphosphorylated tau-induced disruption of microtubule network. Using Nocodozol...

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Autori principali: Li, Bin, Chohan, Muhammad Omar, Grundke-Iqbal, Inge, Iqbal, Khalid
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191942/
https://ncbi.nlm.nih.gov/pubmed/17372746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-007-0207-8
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