Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor

Activated G protein-coupled receptors (GPCRs) are phosphorylated and interact with β-arrestins, which mediate desensitization and endocytosis. Endothelin-converting enzyme-1 (ECE-1) degrades neuropeptides in endosomes and can promote recycling. Although endocytosis, dephosphorylation, and recycling...

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Detalhes bibliográficos
Main Authors: Murphy, Jane E., Roosterman, Dirk, Cottrell, Graeme S., Padilla, Benjamin E., Feld, Micha, Brand, Eva, Cedron, Wendy J., Bunnett, Nigel W., Steinhoff, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Receptors and Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191565/
https://ncbi.nlm.nih.gov/pubmed/21795521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00096.2011
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