Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling

Neuropeptide signaling requires the presence of G protein-coupled receptors (GPCRs) at the cell surface. Activated GPCRs interact with β-arrestins, which mediate receptor desensitization, endocytosis, and mitogenic signaling, and the peptide–receptor–arrestin complex is sequestered into endosomes. A...

Full description

Saved in:
Bibliographic Details
Main Authors: Roosterman, Dirk, Cottrell, Graeme S., Padilla, Benjamin E., Muller, Laurent, Eckman, Christopher B., Bunnett, Nigel W., Steinhoff, Martin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913888/
https://ncbi.nlm.nih.gov/pubmed/17592116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701910104
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items