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Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
Neuropeptide signaling requires the presence of G protein-coupled receptors (GPCRs) at the cell surface. Activated GPCRs interact with β-arrestins, which mediate receptor desensitization, endocytosis, and mitogenic signaling, and the peptide–receptor–arrestin complex is sequestered into endosomes. A...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913888/ https://ncbi.nlm.nih.gov/pubmed/17592116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701910104 |
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