Potent Inhibition of Norwalk Virus by Cyclic Sulfamide Derivatives

A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 μM, TD(50) 50 μM) has been prospected by exploiting multiple points of diversity a...

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Detalhes bibliográficos
Main Authors: Dou, Dengfeng, Tiew, Kok-Chuan, He, Guijia, Mandadapu, Sivakoteswara Rao, Aravapalli, Sridhar, Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191538/
https://ncbi.nlm.nih.gov/pubmed/21925886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.054
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