Design, Synthesis, and Evaluation of Inhibitors of Norwalk Virus 3C Protease

The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-bas...

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Detalhes bibliográficos
Main Authors: Tiew, Kok-Chuan, He, Guijia, Aravapalli, Sridhar, Mandadapu, Sivakoteswara Rao, Gunnam, Mallikarjuna Reddy, Alliston, Kevin R., Lushington, Gerald H., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159713/
https://ncbi.nlm.nih.gov/pubmed/21802286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.07.016
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