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Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles
A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit noro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389214/ https://ncbi.nlm.nih.gov/pubmed/22698498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.055 |
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