Potent Inhibition of Norovirus 3CL Protease by Peptidyl α-Ketoamides and α-Ketoheterocycles

A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit noro...

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Bibliografski detalji
Glavni autori: Mandadapu, Sivakoteswara Rao, Weerawarna, Pathum M., Gunnam, Mallikarjuna Reddy, Alliston, Kevin R., Lushington, Gerald H., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389214/
https://ncbi.nlm.nih.gov/pubmed/22698498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.055
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