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Potent Inhibition of Norovirus by Dipeptidyl α-Hydroxyphosphonate Transition State Mimics

The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Mandadapu, Sivakoteswara Rao, Gunnam, Mallikarjuna Reddy, Kankanamalage, Anushka C. Galasiti, Uy, Roxanne Adeline Z., Alliston, Kevin R., Lushington, Gerald H., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916958/
https://ncbi.nlm.nih.gov/pubmed/24054123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.073
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