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Potent Inhibition of Norovirus by Dipeptidyl α-Hydroxyphosphonate Transition State Mimics
The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4916958/ https://ncbi.nlm.nih.gov/pubmed/24054123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.073 |
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