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Runx2 Protein Expression Utilizes the Runx2 P1 Promoter to Establish Osteoprogenitor Cell Number for Normal Bone Formation

The Runt-related transcription factor, Runx2, is essential for osteogenesis and is controlled by both distal (P1) and proximal (P2) promoters. To understand Runx2 function requires determination of the spatiotemporal activity of P1 and P2 to Runx2 protein production. We generated a mouse model in wh...

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Detalhes bibliográficos
Main Authors: Liu, Julie C., Lengner, Christopher J., Gaur, Tripti, Lou, Yang, Hussain, Sadiq, Jones, Marci D., Borodic, Brent, Colby, Jennifer L., Steinman, Heather A., van Wijnen, Andre J., Stein, Janet L., Jones, Stephen N., Stein, Gary S., Lian, Jane B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191046/
https://ncbi.nlm.nih.gov/pubmed/21676869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241505
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