FAT10 Protein Binds to Polyglutamine Proteins and Modulates Their Solubility

Expansion of polyglutamine (pQ) chain by expanded CAG repeat causes dominantly inherited neurodegeneration such as Huntington disease, dentatorubral-pallidoluysian atrophy (DRPLA), and numbers of other spinocerebellar ataxias. Expanded pQ disrupts the stability of the pQ-harboring protein and increa...

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Bibliographic Details
Main Authors: Nagashima, Yu, Kowa, Hisatomo, Tsuji, Shoji, Iwata, Atsushi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191000/
https://ncbi.nlm.nih.gov/pubmed/21757738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261032
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