p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies

Oligomer formation and accumulation of pathogenic proteins are key events in the pathomechanisms of many neurodegenerative diseases, such as Alzheimer disease, ALS, and the polyglutamine (polyQ) diseases. The autophagy-lysosome degradation system may have therapeutic potential against these diseases...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Saitoh, Yuji, Fujikake, Nobuhiro, Okamoto, Yuma, Popiel, H. Akiko, Hatanaka, Yusuke, Ueyama, Morio, Suzuki, Mari, Gaumer, Sébastien, Murata, Miho, Wada, Keiji, Nagai, Yoshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340391/
https://ncbi.nlm.nih.gov/pubmed/25480790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.590281
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