Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway

Recent studies have implicated a poorly defined alternative pathway of nonhomologous end joining (alt-NHEJ) in the generation of large deletions and chromosomal translocations that are frequently observed in cancer cells. Here, we describe an interaction between two factors, hMre11/hRad50/Nbs1 (MRN)...

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Main Authors: Della-Maria, Julie, Zhou, Yi, Tsai, Miaw-Sheue, Kuhnlein, Jeff, Carney, James P., Paull, Tanya T., Tomkinson, Alan E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190819/
https://ncbi.nlm.nih.gov/pubmed/21816818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274159
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