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Exonuclease Function of Human Mre11 Promotes Deletional Nonhomologous End Joining

DNA double-stranded breaks (DSBs) are lethal if not repaired and are highly mutagenic if misrepaired. Nonhomologous end joining (NHEJ) is one of the major DSB repair pathways and can rejoin the DSB ends either precisely or with mistakes. Recent evidence suggests the existence of two NHEJ subpathways...

詳細記述

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書誌詳細
主要な著者: Zhuang, Jing, Jiang, Guochun, Willers, Henning, Xia, Fen
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781611/
https://ncbi.nlm.nih.gov/pubmed/19744924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059444
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