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Exonuclease Function of Human Mre11 Promotes Deletional Nonhomologous End Joining

DNA double-stranded breaks (DSBs) are lethal if not repaired and are highly mutagenic if misrepaired. Nonhomologous end joining (NHEJ) is one of the major DSB repair pathways and can rejoin the DSB ends either precisely or with mistakes. Recent evidence suggests the existence of two NHEJ subpathways...

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Autores principales: Zhuang, Jing, Jiang, Guochun, Willers, Henning, Xia, Fen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781611/
https://ncbi.nlm.nih.gov/pubmed/19744924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059444
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