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Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining
Nonhomologous end joining repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. Ku, XRCC4/Ligase IV (XL), and XLF have a remarkable mismatched end (MEnd) ligase activity, particularly for ends with mismatched 3′ overhangs, but the mechanism has remained obscure. Her...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689955/ https://ncbi.nlm.nih.gov/pubmed/23620595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464115 |
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