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Processing of DNA for nonhomologous end-joining by cell-free extract
In mammalian cells, nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. We have developed a cell-free system capable of processing and joining noncompatible DNA ends. The system had key features of NHEJ in vivo, including dependenc...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549622/ https://ncbi.nlm.nih.gov/pubmed/15692565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600563 |
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