Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

This investigation was pursued to test the use of intracellular antibodies (intrabodies) as a means of blocking the pathogenesis of Huntington's disease (HD). HD is characterized by abnormally elongated polyglutamine near the N terminus of the huntingtin protein, which induces pathological prot...

Full description

Saved in:
Bibliographic Details
Main Authors: Lecerf, Jean-Michel, Shirley, Thomas L., Zhu, Quan, Kazantsev, Aleksey, Amersdorfer, Peter, Housman, David E., Messer, Anne, Huston, James S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC31908/
https://ncbi.nlm.nih.gov/pubmed/11296304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071058398
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items