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An ScFv Intrabody Against the Non-Amyloid Component of Alpha Synuclein Reduces Intracellular Aggregation and Toxicity
Prevention of abnormal misfolding and aggregation of alpha-synuclein (α-syn) protein in vulnerable neurons should be a viable therapeutic strategy for reducing pathogenesis in Parkinson’s disease (PD). The non-amyloid component (NAC) region of α-syn shows strong tendencies to form β-sheet structures...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2359154/ https://ncbi.nlm.nih.gov/pubmed/18237741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.11.096 |
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