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Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease
This investigation was pursued to test the use of intracellular antibodies (intrabodies) as a means of blocking the pathogenesis of Huntington's disease (HD). HD is characterized by abnormally elongated polyglutamine near the N terminus of the huntingtin protein, which induces pathological prot...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2001
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC31908/ https://ncbi.nlm.nih.gov/pubmed/11296304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071058398 |
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