Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

This investigation was pursued to test the use of intracellular antibodies (intrabodies) as a means of blocking the pathogenesis of Huntington's disease (HD). HD is characterized by abnormally elongated polyglutamine near the N terminus of the huntingtin protein, which induces pathological protein–p...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lecerf, Jean-Michel, Shirley, Thomas L., Zhu, Quan, Kazantsev, Aleksey, Amersdorfer, Peter, Housman, David E., Messer, Anne, Huston, James S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11296304/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071058398
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