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Mutant Huntingtin Forms in Vivo Complexes with Distinct Context-Dependent Conformations of the Polyglutamine Segment

Huntington's disease (HD) is caused by an expanded glutamine tract, which confers a novel aggregation-promoting property on the 350-kDa huntingtin protein. Using specific antibodies, we have probed the structure of the polyglutamine segment in mutant huntingtin complexes formed in cell culture from...

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Principais autores: Francesca Persichetti, Flavia Trettel, C.Chris Huang, Cornel Fraefel, H.T.Marc Timmers, James F. Gusella, Marcy E. MacDonald
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 1999-10-01
coleção:Neurobiology of Disease
Assuntos:
Huntington's disease
huntingtin
aggregation
polyglutamine
1F8 mAb.
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996199902607
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