Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Abstract Huntington’s disease (HD) is a late onset, inherited neurodegenerative disorder for which early pathogenic events remain poorly understood. Here we show that mutant exon 1 HTT proteins are recruited to a subset of cytoplasmic aggregates in the cell bodies of neurons in brain sections from p...

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Autores principales:	Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2021-04-01
Colección:	Acta Neuropathologica Communications
Materias:	Huntington’s disease Correlative light and electron microscopy Electron tomography Huntingtin aggregation Polyglutamine Endolysosomal system
Acceso en línea:	https://doi.org/10.1186/s40478-021-01172-z
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