Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity

The Notch signal transduction pathway mediates important cellular functions through direct cell-to-cell contact. Deregulation of Notch activity can lead to an altered cell proliferation and has been linked to many human cancers. Casein kinase 2 (CK2), a ubiquitous kinase, regulates several cellular...

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Bibliographic Details
Main Authors: Ranganathan, Prathibha, Vasquez-Del Carpio, Rodrigo, Kaplan, Fred M., Wang, Hong, Gupta, Ashu, VanWye, Jeffrey D., Capobianco, Anthony J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190692/
https://ncbi.nlm.nih.gov/pubmed/21685388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243600
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