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Extension of the Notch intracellular domain Ankyrin Repeat Stack by NRARP Promotes Feedback Inhibition of Notch Signaling
Canonical Notch signaling relies on regulated proteolysis of the receptor Notch to generate a nuclear effector that induces the transcription of Notch-responsive genes. In higher organisms, one Notch-responsive gene that is activated in many different cell types encodes the Notch-regulated ankyrin r...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7212804/ https://ncbi.nlm.nih.gov/pubmed/31690634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay2369 |
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