Extension of the Notch intracellular domain Ankyrin Repeat Stack by NRARP Promotes Feedback Inhibition of Notch Signaling

Canonical Notch signaling relies on regulated proteolysis of the receptor Notch to generate a nuclear effector that induces the transcription of Notch-responsive genes. In higher organisms, one Notch-responsive gene that is activated in many different cell types encodes the Notch-regulated ankyrin r...

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Pubblicato in:Sci Signal
Autori principali: Jarrett, Sanchez M., Seegar, Tom C. M., Andrews, Mark, Adelmant, Guillaume, Marto, Jarrod A., Aster, Jon C., Blacklow, Stephen C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212804/
https://ncbi.nlm.nih.gov/pubmed/31690634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay2369
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