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A genome wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction
Several proteins including the replication licensing factor CDT1 and the histone methyltransferase SET8 are targeted for proteolysis during DNA replication and repair by the E3 ubiquitin ligase CRL4(CDT2). CRL4(CDT2) function is coupled to replication and repair because it only ubiquitinates substra...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3190166/ https://ncbi.nlm.nih.gov/pubmed/21981919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.036 |
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