CRL4(Cdt2)-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

The proper coordination between DNA replication and mitosis during cell cycle progression is crucial for genomic stability. During G2 and mitosis, Set8 catalyzes monomethylation of histone H4 on lysine 20 (H4K20me1), which promotes chromatin compaction. Set8 levels decline in S phase, but why and ho...

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Detaylı Bibliyografya
Asıl Yazarlar: Centore, Richard C., Havens, Courtney G., Manning, Amity L., Li, Ju-Mei, Flynn, Rachel Litman, Tse, Alice, Jin, Jianping, Dyson, Nicholas J., Walter, Johannes C., Zou, Lee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957874/
https://ncbi.nlm.nih.gov/pubmed/20932472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.015
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