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A genome wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction

Several proteins including the replication licensing factor CDT1 and the histone methyltransferase SET8 are targeted for proteolysis during DNA replication and repair by the E3 ubiquitin ligase CRL4(CDT2). CRL4(CDT2) function is coupled to replication and repair because it only ubiquitinates substra...

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Detalhes bibliográficos
Main Authors: Raman, Malavika, Havens, Courtney G., Walter, Johannes C., Harper, J. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190166/
https://ncbi.nlm.nih.gov/pubmed/21981919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.036
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